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dictyNews Volume 43 Number 22
dictyNews
Electronic Edition
Volume 43, number 22
September 22, 2017
Please submit abstracts of your papers as soon as they have been
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Abstracts
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Isolation, Synthesis and Biological Activity of Chlorinated
Alkylresorcinols from Dictyostelium Cellular Slime Molds
Haruhisa Kikuchi1, Ikuko Ito1, Katsunori Takahashi2, Hirotaka
Ishigaki2, Kyoichi Iizumi2, Yuzuru Kubohara2, Yoshiteru Oshima1
1Graduate School of Pharmaceutical Sciences, Tohoku University,
6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
2Department of Medical Technology, Faculty of Health Science,
Gunma Paz University, 1-7-1, Tonyamachi, Takasaki 370-0006, Japan
3Graduate School of Health and Sports Science, Juntendo University,
1-1 Hiraga-gakuendai, Inzai, Chiba 270-1695, Japan
J. Nat. Prod., in press.
Eight chlorinated alkylresorcinols, monochasiol A–H (1–8), were
isolated from the fruiting bodies of Dictyostelium monochasioides.
Compounds 1–8 were synthesized to confirm their structures and
to obtain sufficient material for performing biological tests.
Monochasiol A (1) selectively inhibited the concanavalin A-induced
interleukin-2 production in Jurkat cells, a human T lymphocyte cell
line. Monochasiols were biogenetically synthesized by the combination
of biosynthetic enzymes relating to the principal polyketides, MPBD
and DIF-1, produced by Dictyostelium discoideum.
submitted by: Haruhisa Kikuchi [fhal@mail.pharm.tohoku.ac.jp]
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[End dictyNews, volume 43, number 22]
