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dictyNews Volume 42 Number 23
dictyNews
Electronic Edition
Volume 42, number 23
September 30, 2016
Please submit abstracts of your papers as soon as they have been
accepted for publication by sending them to dicty@northwestern.edu
or by using the form at
http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit.
Back issues of dictyNews, the Dicty Reference database and other
useful information is available at dictyBase - http://dictybase.org.
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Abstracts
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Web of Stories Interview of John Bonner - Video
I was interviewed for Web of Stories a few months ago on the story
of my life and the video is now online. Just search for Web of Stories
or directly go to this link:
http://www.webofstories.com/play/Bonner/1
The interview is largely based on my published autobiography. It is
too long — fit only for those who run the marathon. You can quit at
the 5 mile marker!
submitted by: John Bonner [jtbonner@princeton.edu]
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The PARP family: insights into functional aspects of poly(ADP-ribose)
polymerase-1 in cell growth and survival
T. Jubin1, A. Kadam1, M. Jariwala1, S. Bhatt1, S. Sutariya1, A.R. Gani1,
S. Gautam2, R. Begum1
1Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao
University of Baroda, Vadodara, Gujarat, India.
2Food Technology Division, Bhabha Atomic Research Centre, Mumbai, India.
Cell Proliferation, 49: 421– 437. doi: 10.1111/cpr.12268
PARP family members can be found spread across all domains and continue
to be essential molecules from lower to higher eukaryotes. Poly (ADP-ribose)
polymerase 1 (PARP-1), newly termed ADP-ribosyltransferase D-type 1
(ARTD1), is a ubiquitously expressed ADP-ribosyltransferase (ART) enzyme
involved in key cellular processes such as DNA repair and cell death. This
review assesses current developments in PARP-1 biology and activation
signals for PARP-1, other than conventional DNA damage activation.
Moreover, many essential functions of PARP-1 still remain elusive. PARP-1
is found to be involved in a myriad of cellular events via conservation of
genomic integrity, chromatin dynamics and transcriptional regulation. This
article briefly focuses on its other equally important overlooked functions
during growth, metabolic regulation, spermatogenesis, embryogenesis,
epigenetics and differentiation. Understanding the role of PARP-1, its
multidimensional regulatory mechanisms in the cell and its dysregulation
resulting in diseased states, will help in harnessing its true therapeutic
potential.
submitted by: Sandip Sutariya [sandeepsutariya@gmail.com]
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Extracellular matrix dynamics and functions in the social amoeba
Dictyostelium: A critical review
Robert J. Huber (a)* and Danton H. O’Day (b,c)
(a) Department of Biology, Trent University, Peterborough, Ontario, Canada
(b) Department of Cell & Systems Biology, University of Toronto, Toronto,
Ontario, Canada
(c) Department of Biology, University of Toronto Mississauga, Mississauga,
Ontario, Canada
Biochimica et Biophysica Acta - General Subjects
Background: The extracellular matrix (ECM) is a dynamic complex of
glycoproteins, proteoglycans, carbohydrates, and collagen that serves as
an interface between mammalian cells and their extracellular environment.
Essential for normal cellular homeostasis, physiology, and events that occur
during development, it is also a key functionary in a number of human
diseases including cancer. The social amoeba Dictyostelium discoideum
secretes an ECM during multicellular development that regulates
multicellularity, cell motility, cell differentiation, and morphogenesis, and
provides structural support and protective layers to the resulting
differentiated cell types. Proteolytic processing within the Dictyostelium
ECM leads to specific bioactive factors that regulate cell motility and
differentiation.Scope of Review: Here we review the structure and functions
of the Dictyostelium ECM and its role in regulating multicellular development.
The questions and challenges that remain and how they can be answered
are also discussed.
Major Conclusions: The Dictyostelium ECM shares many of the features
of mammalian and plant ECM, and thus presents an excellent system for
studying the structure and function of the ECM.
General Significance: As a genetically tractable model organism,
Dictyostelium offers the potential to further elucidate ECM functions,
and to possibly reveal previously unknown roles for the ECM.
submitted by: Robert Huber [roberthuber@trentu.ca]
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[End dictyNews, volume 42, number 23]
