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dictyNews Volume 43 Number 04
dictyNews
Electronic Edition
Volume 43, number 4
March 1, 2017
Please submit abstracts of your papers as soon as they have been
accepted for publication by sending them to dicty@northwestern.edu
or by using the form at
http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit.
Back issues of dictyNews, the Dicty Reference database and other
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Abstracts
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Functional interaction of PkcA and PldB regulate aggregation and
development in Dictyostelium discoideum
Sean Singh, Wasima Mohamed, Annelie Aguessy, Ella Dyetta, Shriraj
Shah, Mohammedasad Khan, Ramamurthy Baskar, Derrick Brazill,*
Cellular Signalling, in press
Multicellular development in Dictyostelium discoideum involves
tightly regulated signaling events controlling the entry into development,
initiation of aggregation and chemotaxis, and cellular differentiation.
Here we show that PkcA, a Dictyostelium discoideum Protein Kinase
C-orthologue, is involved in quorum sensing and the initiation of
development, as well as cAMP sensing during chemotaxis. Additionally,
by epistasis analysis we provide evidence that PkcA and PldB (a
Phospholipase D-orthologue) functionally interact to regulate
aggregation, differentiation, and cell-cell adhesion during development.
Finally, we show that PkcA acts as a positive regulator of intracellular
PLD-activity during development. Taken together, our results suggest
that PkcA act through PldB, by regulating PLD-activity, in order to
control events during development.
submitted by: Derrick Brazill [brazill@genectr.hunter.cuny.edu]
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[End dictyNews, volume 43, number 4]
