dictyNews Volume 43 Number 04

Published in

· 1 year ago

dictyNews 
Electronic Edition 
Volume 43, number 4 
March 1, 2017 

Please submit abstracts of your papers as soon as they have been 
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http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit. 

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========= 
Abstracts 
========= 

 
Functional interaction of PkcA and PldB regulate aggregation and  
development in Dictyostelium discoideum 

Sean Singh, Wasima Mohamed, Annelie Aguessy, Ella Dyetta, Shriraj  
Shah, Mohammedasad Khan, Ramamurthy Baskar, Derrick Brazill,* 

 
Cellular Signalling, in press 

Multicellular development in Dictyostelium discoideum involves  
tightly regulated signaling events controlling the entry into development,  
initiation of aggregation and chemotaxis, and cellular differentiation.  
Here we show that PkcA, a Dictyostelium discoideum Protein Kinase  
C-orthologue, is involved in quorum sensing and the initiation of  
development, as well as cAMP sensing during chemotaxis. Additionally,  
by epistasis analysis we provide evidence that PkcA and PldB (a  
Phospholipase D-orthologue) functionally interact to regulate  
aggregation, differentiation, and cell-cell adhesion during development.  
Finally, we show that PkcA acts as a positive regulator of intracellular  
PLD-activity during development. Taken together, our results suggest  
that PkcA act through PldB, by regulating PLD-activity, in order to  
control events during development. 

 
submitted by: Derrick Brazill  [brazill@genectr.hunter.cuny.edu] 
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[End dictyNews, volume 43, number 4]