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dictyNews Volume 41 Number 13
dictyNews
Electronic Edition
Volume 41, number 13
June 26, 2015
Please submit abstracts of your papers as soon as they have been
accepted for publication by using the form at
http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit.
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Abstracts
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Development of novel DIF-1 derivatives that selectively suppress
innate immune responses
Van Hai Nguyen,1 Haruhisa Kikuchi,1 Yuzuru Kubohara,2,3 Katsunori
Takahashi,4 Yasuhiro Katou,1 Yoshiteru Oshima,1
1 Graduate School of Pharmaceutical Sciences, Tohoku University
2 Department of Molecular and Cellular Biology, Institute for
Molecular and Cellular Regulation (IMCR), Gunma University
3 Graduate School of Health and Sports Science, Juntendo University
4 Department of Medical Technology, Faculty of Health Science,
Gunma Paz College
Bioorg. Med. Chem. , in press.
The multiple pharmacological activities of differentiation-inducing
factor-1 (DIF-1) of the cellular slime mold Dictyostelium discoideum
led us to examine the use of DIF-1 as a Òdrug templateÓ to develop
promising seed compounds for drug discovery. DIF-1 and its derivatives
were synthesized and evaluated for their regulatory activities in
innate immune responses. We found two new derivatives (4d and 5e)
with highly selective inhibitory activities against production of
the antimicrobial peptide attacin in Drosophila S2 cells and against
production of interleukin-2 in Jurkat cells.
Submitted by Haruhisa Kikuchi [hal@mail.pharm.tohoku.ac.jp]
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[End dictyNews, volume 41, number 13]
