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dictyNews Volume 40 Number 09
dictyNews
Electronic Edition
Volume 40, number 9
March 28, 2014
Please submit abstracts of your papers as soon as they have been
accepted for publication by sending them to dicty@northwestern.edu
or by using the form at
http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit.
Back issues of dictyNews, the Dicty Reference database and other
useful information is available at dictyBase - http://dictybase.org.
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Abstracts
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Intracellular killing of bacteria: is Dictyostelium a model macrophage or an alien?
Cosson P, Lima WC.
Cell Microbiol. 2014 Mar 16. doi: 10.1111/cmi.12291.
Predation of bacteria by phagocytic cells was first developed during evolution
by environmental amoebae. Many of the core mechanisms used by amoebae
to sense, ingest and kill bacteria have also been conserved in specialized
phagocytic cells in mammalian organisms. Here we focus on recent results
revealing how Dictyostelium discoideum senses and kills non-pathogenic
bacteria. In this model, genetic analysis of intracellular killing of bacteria has
revealed a surprisingly complex array of specialized mechanisms. These results
raise new questions on these processes, and challenge current models based
largely on studies in mammalian phagocytes. In addition, recent studies suggest
one additional level on complexity by revealing how Dictyostelium recognizes
specifically various bacterial species and strains, and adapts its metabolism to
process them. It remains to be seen to what extent mechanisms uncovered in
Dictyostelium are also used in mammalian phagocytic cells.
Submitted by Wanessa Lima [wanessa.delima@unige.ch]
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[End dictyNews, volume 40, number 9]
