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dictyNews Volume 38 Number 12
dictyNews
Electronic Edition
Volume 38, number 12
April 27, 2012
Please submit abstracts of your papers as soon as they have been
accepted for publication by sending them to dicty@northwestern.edu
or by using the form at
http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit.
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=========
Abstracts
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Non-Brownian dynamics and strategy of amoeboid cell locomotion
Nishimura, SI, Ueda, M and Sasai, M
Physical Review E 85, 041909 (2012)
Amoeboid cells such as Dictyostelium discoideum and Madin-Darby
canine kidney cells show the non-Brownian dynamics of migration
characterized by the superdiffusive increase of mean-squared
displacement. In order to elucidate the physical mechanism of this
non-Brownian dynamics, a computational model is developed which
highlights a group of inhibitorymolecules for actin polymerization. Based
on this model, we propose a hypothesis that inhibitory molecules are sent
backward in the moving cell to accumulate at the rear of cell. The
accumulated inhibitory molecules at the rear further promote cell locomotion
to form a slow positive feedback loop of the whole-cell scale. The persistent
straightforward migration is stabilized with this feedback mechanism, but the
fluctuation in the distribution of inhibitory molecules and the cell shape
deformation concurrently interrupt the persistent motion to turn the cell into
a new direction. A sequence of switching behaviors between persistent
motions and random turns gives rise to the superdiffusive migration in the
absence of the external guidance signal. In the complex environment with
obstacles, this combined process of persistent motions and random turns
drives the simulated amoebae to solve the maze problem in a highly
efficient way, which suggests the biological advantage for cells to bear
the non-Brownian dynamics.
Other information: Some movies (which are not included in the supporting
material of this paper) are available on youtube!
http://www.youtube.com/user/AmoebaSimulator
Submitted by Shin I.Nishimura [shin@hiroshima-u.ac.jp]
--------------------------------------------------------------------------------------
BOOK CHAPTER
Aiko Amagai
Graduate School of Life Sciences, Tohoku University Japan
Regulatory Mechanism in Sexual and Asexual Cycles of Dictyostelium
p327-344, chapter 15
in ADVANCES IN SELECTED PLANT PHYSIOLOGY ASPECTS
Edited by Giuseppe Montanaro and Bartolomeo Dichio
Publisher: InTech, April, 2012
ISBN 978-953-51-0557-2
Hard cover, 388 pages
Submitted by Aiko Amagai [aiamagai@amber.plala.or.jp]
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[End dictyNews, volume 38, number 12]
