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dictyNews Volume 37 Number 15
dictyNews
Electronic Edition
Volume 37, number 15
December 9, 2011
Please submit abstracts of your papers as soon as they have been
accepted for publication by sending them to dicty@northwestern.edu
or by using the form at
http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit.
Back issues of dictyNews, the Dicty Reference database and other
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=========
Abstracts
=========
Transcriptional Repression by a Bzip Protein Regulates Dictyostelium
Prespore Differentiation
Beatriz Nuez-Corcuera, Joanna L. Birch, Yoko Yamada and
Jeffrey G. Williams+
College of Life Sciences, Welcome Trust Building, University of Dundee,
Dow St., Dundee DD1 5EH UK
PLoS One, in Press
In response to the signaling polyketide DIF-1 DimB directly activates
transcription of the ecmB gene in pstB cells; a subset of the prestalk cells
that are the precursors of the basal disc. We show that the promoter of
pspA, a prespore-specific gene, also contains a DimB binding site.
Mutation of this site causes ectopic expression in the prestalk region and
ChIP analysis shows that DIF-1 induces binding of DimB to the pspA
promoter. DIF-1 represses pspA gene expression in a suspension cell
assay but this repression is abrogated in a dimB null strain. These results
suggest a coupled control mechanism, whereby the same DIF-DimB
signaling pathway that directly activates ecmB gene expression directly
represses pspA gene expression.
Submitted by Jeff Williams [j.g.williams@dundee.ac.uk]
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[End dictyNews, volume 37, number 15]
